The Science Of Addiction: Genetics And The Brain
- Funding
The content here is based upon work funded by the Utah State Board of Education and a Science Education Drug Abuse Partnership Award , from The National Institute on Drug Abuse, National Institutes of Health Grant Number R25DA15461.
The contents provided here are solely the responsibility of the authors and do not necessarily represent the official views of the funders.
Drug Type And Route Of Administration
Drugs are taken by humans through different routes of administration, including most commonly via oral consumption, intravenous or subcutaneous injection, or inhalation. The route of delivery affects the pharmacological impact that drugs have on the brain and peripheral physiology, producing unique neurobiological changes and vulnerabilities to addiction-like behaviors . Intravenous injection and smoking produce the fastest rise and highest drug concentration in the blood, which is associated with greater DA signaling and neural activity in reward circuits . Notably, the large majority of drug self administration animal models have relied on intravenous or oral consumption drug delivery, which may obscure unique neurobiological and behavioral adaptations produced by other delivery routes. Smoked cannabis and nicotine are among the most consumed drugs by humans, for example, underscoring the need for SUD models that are amenable to inhalation exposure. Recent work has progressed on this front, with technology for vapor-based delivery of cannabis, cannabinoids, nicotine, and other drugs in rodents .
Individual Differences In Substance Use Disorder Vulnerability
Humans exhibit considerable individual differences in SUD characteristics as a function of sex, gender, age, and social and environmental demographics . The factors that promote exaggerated drug use in only a fraction of people are likely myriad, but individual differences in DA system activity and function play a key role . For example, humans with genetic polymorphisms that result in elevated DA system activity show greater reward cue-evoked striatal activity and craving that could denote a predisposition toward exaggerated drug use . Consistent with this, in animal models, variability in DA signaling and expression of striatal DA receptors is associated with higher drug cue responsivity and relapse . Furthermore, at certain stages of the estrus cycle, female rodents have larger NAc DA signals in response to cocaine and cocaine-associated cues, which is thought to underlie their generally higher propensity for addiction-like behaviors .
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Dr Montes: Neurobiology Of Addiction Part 3 The Treatment Center
Dr. Montes: Neurobiology of Addiction Part 3 The Treatment Center Dr. Montes shares his insight on the neurobiology of addiction. Call 446-1342 for a confidential consultation. We are a nationally recognized drug and
House Republicans want drug tests for food-stamp recipients. There’s no good
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The drug testing of SNAP recipients is yet another ideological sideshow that disfigures substance-abuse policy. It falsely implies that substance use disorders are a widespread for abuse or dependence on alcohol or illicit drugs. These are the
Hand Transplantation to Become Much More Practical With Swiss Research
Filed under:drug abuse treatment statistics
The main problem with this treatment is that patients have to be immunosuppressed, i.e. their total immune system has to be brought down with drugs to prevent their organism rejecting the foreign tissue. This treatment is associated with undesirable
Methadone is an effective drug treatment and should continue to be used to
Filed under:drug abuse treatment statistics
I stopped injecting, stopped using drugs. Got to know my family again.” Dr Kidd said: “The perceived failure by some of the current Scottish strategy, the Road to Recovery, has been fuelled by drug death statistics which had revealed a continuing
Dr Montes: Neurobiology Of Addiction Part 1 The Treatment Center
Dr. Montes: Neurobiology of Addiction Part 1 The Treatment Center Dr. Montes shares his insight on the neurobiology of addiction. Call 446-1342 for a confidential consultation. We are a nationally recognized drug and
Congresswoman: Obamacare creating health insurance monopolies
Filed under:drug abuse foundation
Renee Ellmers raised awareness of a new problem with Obamacare’s implementation: the creation of private-sector health insurance monopolies that will limit Americans’ provider choices. The major health insurance company Blue Cross Blue Shield, which
Minnesota’s Hazelden, California’s Betty Ford Center to merge
Filed under:drug abuse foundation
The melding of the two addiction care powerhouses comes on the eve of federal health reform measures that will require insurance companies to cover substance abuse and mental health treatment. For the first time, millions of Americans will have access
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Category Iii Risky Substance Use
The DSM criteria for risky use of substances includes âusing substances again and again, even when it puts you in dangerâ and âcontinuing to use, even when you know you have a physical or psychological problem that could have been caused or made worse by the substanceâ. Common decision-making tasks thought to capture these SUD criteria are shown in Figure 1. Recently, animal models of behaviors related to this SUD criterion have become more common, including âriskyâ choice assessment, conflict procedures, and punishment-resistant intake models .
What Is Addiction A Working Definition For Families
As a psychiatrist specializing in addiction, Im often asked to be a guest speaker for various audiences, including families who want to know how to help a loved one struggling with a substance use disorder . In these cases, I like to start by answering the misleadingly basic question, What is addiction? Because an answer to this question truly is the first step towards recovery. When families have an accurate working definition of addiction, they are better equipped to cope with a loved ones disease and help that loved one get effective treatment.
On that note, here is a concise working definition of addiction for anyone whose loved one is struggling with drug or alcohol addiction:
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Dr Montes: Neurobiology Of Addiction Part 1
Dr. Montes: Neurobiology of Addiction Part 1 Dr. Montes shares his insight on the neurobiology of addiction. Call 446-1342 for a confidential consultation. We are a nationally recognized drug and alcohol treatment center committed to providing compassionate care to each of our patients. The Joint Commissions on Accreditations of Health Care Organizations has awarded The Treatment Center Gold Seal Accreditation for our superior quality of care in the substance abuse treatment centers field. Our staff is a team of highly trained, highly skilled addiction professionals who understand the complexities of addiction and treat the disease through contemporary methods. We offer the following services: In-patient Drug and Alcohol Rehabilitation Full Medical Drug and Alcohol Detox by Board Certified Physicians Dual Diagnosis Substance Abuse Treatment Individual and Group Therapy Holistic Pain Treatment Acupuncture Massage Therapy Cognitive Behavior Therapy EMDR Therapy In addition to our traditional residential treatment program, we offer a Christian substance abuse treatment center, Road Less Traveled. We also offer our GO program, designed to assist our patients transition from in-patient treatment to sober living.
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Disclaimer: Consult a medical professional for medical advice. Stopping psychiatric drugs, especially abruptly, can be dangerous, as withdrawal effects may be severe, disabling or life-threatening. This article is not meant to deter anyone from recovery, or what they find helpful. Rather, this article is meant to shine a light on what leads to, or hinders, long-term outcomes and to offer relevant, and perhaps unknown solutions. This article does not represent the views, opinions, or experiences of any employer or organization with which I may be affiliated.
They said it wasnt a gateway drug. My homie was taking subs and he aint wake up. The whole while, these billionaires, they kicked up, paying out Congress so we take their drugs. ~ Macklemore
In Macklemores lyrics, you could substitute OxyContin for Suboxone and it would accurately describe two of the main reasons why the opiate crisis got so bad: false marketing and corporate greed. I believe we are at the beginning of another epidemic, and its playing out in the addiction treatment industry .
During my professional and personal time in addiction recovery, I began to see an increase in the medications used in treatment. I started to wonder, How many medications does it take to get sober? I asked that question because I wasnt seeing a lot of people recover using the medications. In fact.
Is it detox or a disorder?
Why arent we repairing the leaky hole?
But we can get out of it.
Whats the solution?
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Dr Montes: Neurobiology Of Addiction Part 2
Dr. Montes: Neurobiology of Addiction Part 2 Dr. Montes shares his insight on the neurobiology of addiction. Call 446-1342 for a confidential consultation. We are a nationally recognized drug and alcohol treatment center committed to providing compassionate care to each of our patients. The Joint Commissions on Accreditations of Health Care Organizations has awarded The Treatment Center Gold Seal Accreditation for our superior quality of care in the substance abuse treatment centers field. Our staff is a team of highly trained, highly skilled addiction professionals who understand the complexities of addiction and treat the disease through contemporary methods. We offer the following services: In-patient Drug and Alcohol Rehabilitation Full Medical Drug and Alcohol Detox by Board Certified Physicians Dual Diagnosis Substance Abuse Treatment Individual and Group Therapy Holistic Pain Treatment Acupuncture Massage Therapy Cognitive Behavior Therapy EMDR Therapy In addition to our traditional residential treatment program, we offer a Christian substance abuse treatment center, Road Less Traveled. We also offer our GO program, designed to assist our patients transition from in-patient treatment to sober living.
Dr Montes: Neurobiology Of Addiction Part 2 The Treatment Center
Dr. Montes: Neurobiology of Addiction Part 2 The Treatment Center Dr. Montes shares his insight on the neurobiology of addiction. Call 446-1342 for a confidential consultation. We are a nationally recognized drug and
Family sues Dr. Phil, treatment center
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SYRACUSE, Utah The family of a teenage girl who claims she was berated on television by Dr. Phil and then sent to a residential treatment center in Utah where she was falsely imprisoned, has filed a civil lawsuit. Terri and David Myers, on behalf ofRead more on Hornell Evening Tribune
Cancer Treatment Centers of America announces move to Florida
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Dr Montes: Neurobiology Of Addiction Part 5
Dr. Montes: Neurobiology of Addiction Part 5 Dr. Montes shares his insight on the neurobiology of addiction. Call 446-1342 for a confidential consultation. We are a nationally recognized drug and alcohol treatment center committed to providing compassionate care to each of our patients. The Joint Commissions on Accreditations of Health Care Organizations has awarded The Treatment Center Gold Seal Accreditation for our superior quality of care in the substance abuse treatment centers field. Our staff is a team of highly trained, highly skilled addiction professionals who understand the complexities of addiction and treat the disease through contemporary methods. We offer the following services: In-patient Drug and Alcohol Rehabilitation Full Medical Drug and Alcohol Detox by Board Certified Physicians Dual Diagnosis Substance Abuse Treatment Individual and Group Therapy Holistic Pain Treatment Acupuncture Massage Therapy Cognitive Behavior Therapy EMDR Therapy In addition to our traditional residential treatment program, we offer a Christian substance abuse treatment center, Road Less Traveled. We also offer our GO program, designed to assist our patients transition from in-patient treatment to sober living.
Responses To Dr Montes: Neurobiology Of Addiction Part 1 The Treatment Center
- The Treatment Center:
Dr. Montes explains what happens to the brain after a person has developedthe disease of addiction.
This video will change the way you see this disease and the people whosuffer from it.?
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Thank you for taking advantage of our online resources!
- Humberto Rodrigues:
Dear Dr. Montes I am very grateful for your email, I tried your contact youbut without success. In fact, i could not access your response. Sincerely,Humberto Rodrigues
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Dr. Montes is brilliant. He changed my life by using such simplifedterminology. Just dont ever forget to use the visuals! -) Thank you,forever.
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Dr.Montes, i am psychologist and I starting to do some research in thearea, . please i will like to know your opinion on the following aspects:If addiction is a phenomenon of learning, why the technique of exposureseems not to be efective? the attentional bias for stimuli motivationallyappetitive is distributed as during the development ofaddiction? when they begin to be automatic?
- Humberto Rodrigues:
Probably the best presentation Ive ever seen.fantastic
- Humberto Rodrigues:
I thank you! That is so brilliant and simple explanation, with atherapeutic and preventive character, which is an example of reflexion
- w27dj:
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Dopamine Circuit Mechanisms Of Addiction
- 1Department of Neuroscience, University of Minnesota, Minneapolis, MN, United States
- 2Medical Discovery Team on Addiction, University of Minnesota, Minneapolis, MN, United States
- 3Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, United States
Addiction is a complex disease that impacts millions of people around the world. Clinically, addiction is formalized as substance use disorder , with three primary symptom categories: exaggerated substance use, social or lifestyle impairment, and risky substance use. Considerable efforts have been made to model features of these criteria in non-human animal research subjects, for insight into the underlying neurobiological mechanisms. Here we review evidence from rodent models of SUD-inspired criteria, focusing on the role of the striatal dopamine system. We identify distinct mesostriatal and nigrostriatal dopamine circuit functions in behavioral outcomes that are relevant to addictions and SUDs. This work suggests that striatal dopamine is essential for not only positive symptom features of SUDs, such as elevated intake and craving, but also for impairments in decision making that underlie compulsive behavior, reduced sociality, and risk taking. Understanding the functional heterogeneity of the dopamine system and related networks can offer insight into this complex symptomatology and may lead to more targeted treatments.
